Peptide LibraryResearch statistics
Eptifibatide research: publications and trials
At a glance
Publications, all years
1,134
Since 1994
Publications in 2026 so far
10
Through November 1, 2026
Human clinical research
50.6%
561 of 1,109 classified
Registered clinical trials
30
ClinicalTrials.gov
Randomized controlled trials
193
Publications reporting an RCT in people
Systematic reviews and meta-analyses
37
Preclinical studies
20.9%
61 animal · 160 in vitro · 11 computational
Records that only mention it
271
Not counted above
Status in the library: FDA-approved. 25 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Eptifibatide publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1994 | 0 | 2 | 0 | 2 | 4 |
| 1995 | 2 | 0 | 3 | 0 | 5 |
| 1996 | 3 | 0 | 2 | 0 | 5 |
| 1997 | 5 | 1 | 6 | 5 | 17 |
| 1998 | 4 | 3 | 14 | 7 | 28 |
| 1999 | 11 | 3 | 22 | 11 | 47 |
| 2000 | 29 | 6 | 30 | 9 | 74 |
| 2001 | 36 | 21 | 20 | 10 | 87 |
| 2002 | 34 | 16 | 16 | 7 | 73 |
| 2003 | 43 | 12 | 21 | 10 | 86 |
| 2004 | 49 | 16 | 13 | 2 | 80 |
| 2005 | 27 | 17 | 11 | 3 | 58 |
| 2006 | 30 | 13 | 5 | 8 | 56 |
| 2007 | 21 | 3 | 6 | 0 | 30 |
| 2008 | 19 | 7 | 6 | 2 | 34 |
| 2009 | 20 | 11 | 4 | 7 | 42 |
| 2010 | 17 | 12 | 8 | 6 | 43 |
| 2011 | 19 | 8 | 6 | 2 | 35 |
| 2012 | 23 | 7 | 6 | 3 | 39 |
| 2013 | 21 | 8 | 2 | 2 | 33 |
| 2014 | 21 | 9 | 6 | 3 | 39 |
| 2015 | 13 | 3 | 3 | 1 | 20 |
| 2016 | 14 | 7 | 2 | 0 | 23 |
| 2017 | 10 | 5 | 1 | 1 | 17 |
| 2018 | 9 | 4 | 3 | 0 | 16 |
| 2019 | 13 | 6 | 5 | 1 | 25 |
| 2020 | 10 | 3 | 1 | 0 | 14 |
| 2021 | 9 | 9 | 2 | 0 | 20 |
| 2022 | 12 | 9 | 1 | 1 | 23 |
| 2023 | 8 | 2 | 6 | 0 | 16 |
| 2024 | 10 | 2 | 1 | 1 | 14 |
| 2025 | 12 | 6 | 1 | 2 | 21 |
| 2026 (to date) | 7 | 1 | 1 | 1 | 10 |
Study types
| Review | 197 |
|---|---|
| Randomized controlled trial | 193 |
| In vitro study | 160 |
| Observational human study | 160 |
| Case report | 137 |
| Editorial, letter or other | 75 |
| Other clinical trial | 71 |
| Animal study | 61 |
| Meta-analysis | 32 |
| Not yet classified | 25 |
| Computational study | 11 |
| Systematic review | 5 |
| Correction or retraction notice | 4 |
| Guideline or consensus | 3 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Cardiovascular | 1,012 |
|---|---|
| Neurological and mental health | 87 |
| Immune system | 55 |
| Tissue repair | 41 |
| Metabolic health | 22 |
| Oncology | 20 |
| Reproductive and sexual health | 19 |
| Antimicrobial and infectious disease | 17 |
| Endocrinology | 13 |
| Musculoskeletal | 5 |
| Dermatology | 4 |
| Gastrointestinal | 2 |
Registered clinical trials
1 of 16 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 18 · Terminated: 6 · Unknown status: 5 · Not yet recruiting: 1
Phase not applicable: 1 · Phase 1 / Phase 2: 3 · Phase 2: 12 · Phase 3: 9 · Phase 4: 5
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Safety and efficacy of adjunctive tirofiban and eptifibatide in acute ischemic stroke: A systematic review and meta-analysis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · January 5, 2026 · Meta-analysis · cited 0 times · open access
PMID 41500359 · DOI 10.1016/j.jstrokecerebrovasdis.2026.108550 · Reviews and meta-analyses
- Eptifibatide as an adjuvant therapy to thrombolysis versus thrombolysis alone in stroke management: a systematic review and meta-analysis of randomized controlled trials.
Journal of thrombosis and thrombolysis · June 22, 2025 · Meta-analysis · cited 1 times
PMID 40544389 · DOI 10.1007/s11239-025-03131-0 · Reviews and meta-analyses
- Glycoprotein IIb/IIIa inhibitors in the treatment of thromboembolic events related to endovascular treatment of cerebral aneurysms-systematic review and meta-analysis.
The neuroradiology journal · March 24, 2023 · Meta-analysis · cited 8 times · open access
PMID 36961079 · DOI 10.1177/19714009231166090 · Reviews and meta-analyses
- Efficacy and safety of a bridging strategy that uses intravenous platelet glycoprotein receptor inhibitors for patients undergoing surgery after coronary stent implantation: a meta-analysis.
BMC cardiovascular disorders · March 24, 2022 · Meta-analysis · cited 8 times · open access
PMID 35331138 · DOI 10.1186/s12872-022-02563-3 · Reviews and meta-analyses
- Efficacy outcomes and safety measures of intravenous tirofiban or eptifibatide for patients with acute ischemic stroke: a systematic review and meta-analysis of prospective studies.
Journal of thrombosis and thrombolysis · November 15, 2021 · Meta-analysis · cited 26 times
PMID 34780001 · DOI 10.1007/s11239-021-02584-3 · Reviews and meta-analyses
- Safety of Glycoprotein IIb-IIIa Inhibitors Used in Stroke-Related Treatment: A Systematic Review and Meta-Analysis.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · January 1, 2020 · Meta-analysis · cited 31 times · open access
PMID 32727211 · DOI 10.1177/1076029620942594 · Reviews and meta-analyses
- Routine Glycoprotein IIb/IIIa Inhibitor Therapy in ST-Segment Elevation Myocardial Infarction: A Meta-analysis.
The Canadian journal of cardiology · May 7, 2019 · Meta-analysis · cited 53 times
PMID 31542257 · DOI 10.1016/j.cjca.2019.05.003 · Reviews and meta-analyses
- Efficacy and safety of eptifibatide versus tirofiban in acute coronary syndrome patients: A systematic review and meta-analysis.
Journal of evidence-based medicine · May 1, 2017 · Meta-analysis · cited 25 times
PMID 28449419 · DOI 10.1111/jebm.12253 · Reviews and meta-analyses
- Bivalirudin Anticoagulant Therapy With or Without Platelet Glycoprotein IIb/IIIa Inhibitors During Transcatheter Coronary Interventional Procedures: A Meta-Analysis.
Medicine · August 1, 2015 · Meta-analysis · cited 10 times · open access
PMID 26266343 · DOI 10.1097/md.0000000000001067 · Reviews and meta-analyses
- Combination therapy of intravenous glycoprotein IIB/IIIA inhibitors and tissue plasminogen activator for acute ischemic stroke.
Neurology India · November 1, 2014 · Meta-analysis · cited 4 times
PMID 25591675 · DOI 10.4103/0028-3886.149385 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes.
The New England journal of medicine · August 1, 1998 · Randomized controlled trial · cited 1,432 times · open access
PMID 9705684 · DOI 10.1056/nejm199808133390704 · Human clinical research
- Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction.
Circulation · June 7, 2004 · Observational human study · cited 1,354 times · open access
PMID 15184279 · DOI 10.1161/01.cir.0000130846.46168.03 · Human clinical research
- Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial.
JAMA · February 1, 2003 · Randomized controlled trial · cited 1,162 times
PMID 12588269 · DOI 10.1001/jama.289.7.853 · Human clinical research
- Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT Investigators.
Circulation · June 1, 2000 · Randomized controlled trial · cited 963 times · open access
PMID 10840005 · DOI 10.1161/01.cir.101.22.2557 · Human clinical research
- ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction--2002: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina).
Circulation · October 1, 2002 · Guideline or consensus · cited 845 times
PMID 12356647 · DOI 10.1161/01.cir.0000037106.76139.53 · Commentary and other
Latest publications
- Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature.
Journal of neurointerventional surgery · October 13, 2026 · Case report · cited 1 times
PMID 41320543 · DOI 10.1136/jnis-2025-024406 · Human clinical research
- Pharmacovigilance analysis of glycoprotein IIb/IIIa inhibitors: A FAERS-based signal detection study.
Medicine · August 1, 2026 · Observational human study · cited 0 times · open access
PMID 42566619 · DOI 10.1097/md.0000000000050132 · Human clinical research
- A Therapeutic Dilemma: Catastrophic ST-Elevation Myocardial Infarction Following Antiplatelet Therapy Interruption in a Patient With JAK2-Positive Polycythemia Vera.
Clinical case reports · July 29, 2026 · Case report · cited 0 times · open access
PMID 42534514 · DOI 10.1002/ccr3.73264 · Human clinical research
- Impact of Using Blended Polymers on the Structural and Functional Attributes of Eptifibatide-Loaded Microspheres.
ACS omega · June 18, 2026 · In vitro study · cited 0 times · open access
PMID 42396058 · DOI 10.1021/acsomega.6c00624 · In vitro studies
- Commentary: Evaluation of the real-world safety of eptifibatide in the treatment of ARDS: results of a disproportionality analysis of FAERS data.
Frontiers in medicine · April 29, 2026 · Editorial, letter or other · cited 0 times · open access
PMID 42136837 · DOI 10.3389/fmed.2026.1835916 · Commentary and other
- Adaptive Antithrombotic Strategy for Tandem Occlusion Stroke: Escalating Therapy After Thrombectomy and Stenting.
Diagnostics (Basel, Switzerland) · April 24, 2026 · Observational human study · cited 0 times · open access
PMID 42121987 · DOI 10.3390/diagnostics16091281 · Human clinical research
- Adjunctive Eptifibatide Administration in ACS Patients Undergoing Percutaneous Coronary Intervention: A Randomized Comparison of Bolus-only Versus Standard Therapy.
American heart journal plus : cardiology research and practice · April 9, 2026 · Randomized controlled trial · cited 0 times · open access
PMID 42058321 · DOI 10.1016/j.ahjo.2026.100781 · Human clinical research
- Evaluation of the real-world safety of eptifibatide in the treatment of ARDS: results of a disproportionality analysis of FAERS data.
Frontiers in medicine · February 26, 2026 · Observational human study · cited 2 times · open access
PMID 41836947 · DOI 10.3389/fmed.2026.1767036 · Human clinical research
- Evaluation of the Rational use of Eptifibatide among Patients with Acute Coronary Syndrome Referred to Shahid Chamran Heart Hospital.
Journal of research in pharmacy practice · February 24, 2026 · Observational human study · cited 0 times · open access
PMID 42846822 · DOI 10.4103/jrpp.jrpp_108_25 · Human clinical research
- Safety and efficacy of adjunctive tirofiban and eptifibatide in acute ischemic stroke: A systematic review and meta-analysis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · January 5, 2026 · Meta-analysis · cited 0 times · open access
PMID 41500359 · DOI 10.1016/j.jstrokecerebrovasdis.2026.108550 · Reviews and meta-analyses
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Eptifibatida; Eptifibatide; Integrelin; Integrilin; Intrifiban
((TITLE_ABS:"Eptifibatida" OR CHEM:"Eptifibatida") OR (TITLE_ABS:"Eptifibatide" OR CHEM:"Eptifibatide") OR (TITLE_ABS:"Integrelin" OR CHEM:"Integrelin") OR (TITLE_ABS:"Integrilin" OR CHEM:"Integrilin") OR (TITLE_ABS:"Intrifiban" OR CHEM:"Intrifiban")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Eptifibatide research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/eptifibatide