Research statistics
Desmopressin research: publications and trials
At a glance
Publications, all years
3,764
Since 1972
Publications in 2026 so far
111
Through November 1, 2026
Human clinical research
60.2%
2,153 of 3,574 classified
Registered clinical trials
103
ClinicalTrials.gov
Randomized controlled trials
318
Publications reporting an RCT in people
Systematic reviews and meta-analyses
90
Preclinical studies
22.2%
642 animal · 140 in vitro · 11 computational
Records that only mention it
2,105
Not counted above
Status in the library: FDA-approved. 190 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Desmopressin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1972 | 1 | 0 | 0 | 0 | 1 |
| 1973 | 1 | 0 | 0 | 2 | 3 |
| 1974 | 2 | 1 | 0 | 7 | 10 |
| 1975 | 9 | 0 | 0 | 3 | 12 |
| 1976 | 12 | 1 | 0 | 4 | 17 |
| 1977 | 9 | 1 | 0 | 5 | 15 |
| 1978 | 14 | 2 | 0 | 11 | 27 |
| 1979 | 14 | 2 | 0 | 15 | 31 |
| 1980 | 14 | 7 | 0 | 11 | 32 |
| 1981 | 18 | 7 | 0 | 10 | 35 |
| 1982 | 21 | 16 | 0 | 11 | 48 |
| 1983 | 21 | 16 | 1 | 10 | 48 |
| 1984 | 29 | 15 | 0 | 18 | 62 |
| 1985 | 25 | 18 | 1 | 16 | 60 |
| 1986 | 40 | 18 | 1 | 10 | 69 |
| 1987 | 35 | 16 | 1 | 4 | 56 |
| 1988 | 41 | 19 | 2 | 21 | 83 |
| 1989 | 44 | 15 | 5 | 16 | 80 |
| 1990 | 51 | 26 | 10 | 13 | 100 |
| 1991 | 47 | 17 | 7 | 11 | 82 |
| 1992 | 39 | 21 | 4 | 16 | 80 |
| 1993 | 48 | 24 | 10 | 10 | 92 |
| 1994 | 35 | 24 | 9 | 7 | 75 |
| 1995 | 47 | 20 | 7 | 13 | 87 |
| 1996 | 38 | 24 | 7 | 8 | 77 |
| 1997 | 55 | 17 | 10 | 11 | 93 |
| 1998 | 48 | 21 | 9 | 4 | 82 |
| 1999 | 55 | 25 | 5 | 6 | 91 |
| 2000 | 40 | 17 | 8 | 1 | 66 |
| 2001 | 49 | 16 | 10 | 0 | 75 |
| 2002 | 45 | 17 | 8 | 5 | 75 |
| 2003 | 40 | 18 | 5 | 9 | 72 |
| 2004 | 57 | 20 | 11 | 1 | 89 |
| 2005 | 48 | 17 | 8 | 3 | 76 |
| 2006 | 37 | 17 | 12 | 3 | 69 |
| 2007 | 56 | 16 | 13 | 3 | 88 |
| 2008 | 41 | 19 | 8 | 3 | 71 |
| 2009 | 39 | 14 | 7 | 4 | 64 |
| 2010 | 49 | 20 | 12 | 3 | 84 |
| 2011 | 55 | 13 | 12 | 5 | 85 |
| 2012 | 38 | 18 | 9 | 7 | 72 |
| 2013 | 49 | 22 | 17 | 7 | 95 |
| 2014 | 55 | 20 | 9 | 3 | 87 |
| 2015 | 43 | 19 | 5 | 4 | 71 |
| 2016 | 47 | 23 | 14 | 8 | 92 |
| 2017 | 41 | 7 | 8 | 16 | 72 |
| 2018 | 51 | 11 | 15 | 6 | 83 |
| 2019 | 39 | 7 | 13 | 7 | 66 |
| 2020 | 59 | 12 | 12 | 10 | 93 |
| 2021 | 59 | 10 | 15 | 8 | 92 |
| 2022 | 60 | 16 | 12 | 5 | 93 |
| 2023 | 55 | 11 | 20 | 6 | 92 |
| 2024 | 54 | 13 | 8 | 2 | 77 |
| 2025 | 63 | 12 | 17 | 14 | 106 |
| 2026 (to date) | 71 | 15 | 13 | 12 | 111 |
Study types
| Case report | 844 |
|---|---|
| Animal study | 642 |
| Other clinical trial | 546 |
| Observational human study | 445 |
| Randomized controlled trial | 318 |
| Review | 300 |
| Editorial, letter or other | 225 |
| Not yet classified | 190 |
| In vitro study | 140 |
| Meta-analysis | 49 |
| Systematic review | 41 |
| Computational study | 11 |
| Guideline or consensus | 9 |
| Correction or retraction notice | 4 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Endocrinology | 1,217 |
|---|---|
| Reproductive and sexual health | 1,210 |
| Neurological and mental health | 1,092 |
| Cardiovascular | 650 |
| Metabolic health | 593 |
| Tissue repair | 232 |
| Immune system | 190 |
| Oncology | 189 |
| Gastrointestinal | 107 |
| Musculoskeletal | 83 |
| Antimicrobial and infectious disease | 64 |
| Dermatology | 46 |
Registered clinical trials
26 of 57 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 60 · Unknown status: 19 · Terminated: 10 · Recruiting: 8 · Enrolling by invitation: 3 · Active, not recruiting: 1 · Not yet recruiting: 1 · Withdrawn: 1
Early phase 1: 1 · Phase not applicable: 36 · Phase 1: 5 · Phase 2: 14 · Phase 2 / Phase 3: 2 · Phase 3: 18 · Phase 4: 27
The 50 most recently started of 103 trials.
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Proactive desmopressin for the prevention of serum sodium overcorrection in moderate-to-severe hyponatremia: a systematic review and meta-analysis.
BMC nephrology · June 25, 2026 · Meta-analysis · cited 0 times · open access
PMID 42351030 · DOI 10.1186/s12882-026-05128-0 · Reviews and meta-analyses
- Effect of Preprocedural Desmopressin on Complications after Kidney Biopsy: A Systematic Review and Meta-Analysis.
Kidney360 · March 12, 2026 · Meta-analysis · cited 0 times · open access
PMID 41817599 · DOI 10.34067/kid.0000001185 · Reviews and meta-analyses
- Effectiveness of Bleeding Control Methods in Rhinoplasty: A Systematic Review and Meta-Analysis.
Archives of plastic surgery · January 30, 2026 · Meta-analysis · cited 1 times · open access
PMID 41625397 · DOI 10.1055/a-2706-1208 · Reviews and meta-analyses
- Efficacy of Desmopressin for Post-Kidney Biopsy Bleeding Complications Prevention: A Systematic Review With Frequentist and Bayesian Meta-Analysis.
Nephrology (Carlton, Vic.) · January 1, 2026 · Meta-analysis · cited 0 times · open access
PMID 41531175 · DOI 10.1111/nep.70164 · Reviews and meta-analyses
- Effect of desmopressin on bleeding outcomes after native renal biopsy: a systematic review and meta-analysis.
Scientific reports · November 7, 2025 · Meta-analysis · cited 0 times · open access
PMID 41203719 · DOI 10.1038/s41598-025-24092-7 · Reviews and meta-analyses
- Desmopressin and bleeding risk in high-risk native kidney biopsy: updated meta-analysis of RCTs and observational studies.
Renal failure · August 31, 2025 · Meta-analysis · cited 3 times · open access
PMID 40887459 · DOI 10.1080/0886022x.2025.2549775 · Reviews and meta-analyses
- Desmopressin for nocturnal enuresis in children.
The Cochrane database of systematic reviews · July 29, 2025 · Meta-analysis · cited 6 times · open access
PMID 40728007 · DOI 10.1002/14651858.cd002112.pub2 · Reviews and meta-analyses
- Efficacy and Safety of Desmopressin in Terms of Bleeding and Transfusion in Cardiac Surgery With Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis.
Heart, lung & circulation · June 4, 2025 · Meta-analysis · cited 5 times · open access
PMID 40473511 · DOI 10.1016/j.hlc.2025.01.003 · Reviews and meta-analyses
- Preoperative Desmopressin for Bleeding Reduction During Rhinoplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Aesthetic plastic surgery · June 2, 2025 · Meta-analysis · cited 3 times
PMID 40456991 · DOI 10.1007/s00266-025-04916-7 · Reviews and meta-analyses
- DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis.
Blood · April 1, 2025 · Meta-analysis · cited 9 times · open access
PMID 39854691 · DOI 10.1182/blood.2024026804 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- The use of DDAVP in children with bleeding disorders.
Pediatric blood & cancer · October 25, 2012 · Review · cited 3,508 times
PMID 23109357 · DOI 10.1002/pbc.24335 · Reviews and meta-analyses
- Abnormal osmotic regulation in trpv4-/- mice.
Proceedings of the National Academy of Sciences of the United States of America · October 27, 2003 · Animal study · cited 797 times · open access
PMID 14581612 · DOI 10.1073/pnas.1735416100 · Animal studies
- 1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands' diseases.
Lancet (London, England) · April 1, 1977 · Other clinical trial · cited 609 times
PMID 67283 · DOI 10.1016/s0140-6736(77)91197-7 · Human clinical research
- Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia.
The New England journal of medicine · January 1, 1983 · Randomized controlled trial · cited 607 times
PMID 6401193 · DOI 10.1056/nejm198301063080102 · Human clinical research
- Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints.
Lancet (London, England) · December 1, 1999 · Meta-analysis · cited 545 times
PMID 10622296 · DOI 10.1016/s0140-6736(99)01264-7 · Reviews and meta-analyses
Latest publications
- Thromboembolic risk associated with desmopressin use in patients with central diabetes insipidus.
European journal of internal medicine · October 27, 2026 · Editorial, letter or other · cited 0 times
PMID 42946621 · DOI 10.1016/j.ejim.2026.107260 · Commentary and other
- Acute colonic pseudo-obstruction with transient failure of oral desmopressin in adipsic arginine vasopressin deficiency.
JCEM case reports · October 27, 2026 · Case report · cited 0 times · open access
PMID 42948338 · DOI 10.1210/jcemcr/luag334 · Human clinical research
- Author's Reply to the Comment on "Factors Affecting the Clinical Response to Desmopressin Treatment for Primary Monosymptomatic Nocturnal Enuresis in Children".
Neurourology and urodynamics · October 26, 2026 · Editorial, letter or other · cited 0 times
PMID 42935132 · DOI 10.1002/nau.70506 · Commentary and other
- Letter to the Editor on: "Factors Affecting the Clinical Response to Desmopressin Treatment for Primary Monosymptomatic Nocturnal Enuresis in Children".
Neurourology and urodynamics · October 23, 2026 · Editorial, letter or other · cited 0 times
PMID 42924449 · DOI 10.1002/nau.70498 · Commentary and other
- Letter to the Editor: "Factors Affecting the Clinical Response to Desmopressin Treatment for Primary Monosymptomatic Nocturnal Enuresis in Children".
Neurourology and urodynamics · October 23, 2026 · Editorial, letter or other · cited 0 times
PMID 42924467 · DOI 10.1002/nau.70503 · Commentary and other
- Evaluation of desmopressin in preventing overcorrection of hyponatraemia among patients with renal dysfunction.
European journal of hospital pharmacy : science and practice · October 23, 2026 · Not yet classified · cited 0 times
PMID 41475799 · DOI 10.1136/ejhpharm-2025-004693 · Not yet classified
- Use of Desmopressin in Spontaneous Nontraumatic Intracerebral Hemorrhage Among Patients Taking Antiplatelet Therapy: Systematic Review and Bayesian Meta-analysis.
Neurocritical care · October 12, 2026 · Review · cited 0 times · open access
PMID 42864513 · DOI 10.1007/s12028-026-02672-3 · Reviews and meta-analyses
- Acute Hemorrhagic Manifestations in a Pregnant Patient With Type 1 von Willebrand Disease: Challenges in Management of Bleeding Disorders During Gestation.
Clinical case reports · October 11, 2026 · Case report · cited 0 times · open access
PMID 42865846 · DOI 10.1002/ccr3.73728 · Human clinical research
- Copeptin and urine concentrating capacity predict kidney function decline in lithium-treated patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · October 8, 2026 · Observational human study · cited 0 times
PMID 42847926 · DOI 10.1093/ndt/gfag219 · Human clinical research
- A Case of Misdiagnosed Pediatric Congenital Nephrogenic Diabetes Insipidus due to AQP2 Variants.
Case reports in pediatrics · October 8, 2026 · Case report · cited 0 times · open access
PMID 42852029 · DOI 10.1155/crpe/9068249 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: 1-deamino-8-D-arginine vasopressin; DDAVP; Desmopresina; Desmopressin; Desmopressine; Desmotabs; Minirin; Nocdurna; Noctiva; Nocutil; Octim
((TITLE_ABS:"1-deamino-8-D-arginine vasopressin" OR CHEM:"1-deamino-8-D-arginine vasopressin" OR TITLE_ABS:"1-deamino8-D-arginine vasopressin" OR CHEM:"1-deamino8-D-arginine vasopressin") OR (TITLE_ABS:"DDAVP" OR CHEM:"DDAVP") OR (TITLE_ABS:"Desmopresina" OR CHEM:"Desmopresina") OR (TITLE_ABS:"Desmopressin" OR CHEM:"Desmopressin") OR (TITLE_ABS:"Desmopressine" OR CHEM:"Desmopressine") OR (TITLE_ABS:"Desmotabs" OR CHEM:"Desmotabs") OR (TITLE_ABS:"Minirin" OR CHEM:"Minirin") OR (TITLE_ABS:"Nocdurna" OR CHEM:"Nocdurna") OR (TITLE_ABS:"Noctiva" OR CHEM:"Noctiva") OR (TITLE_ABS:"Nocutil" OR CHEM:"Nocutil") OR (TITLE_ABS:"Octim" OR CHEM:"Octim")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Desmopressin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/desmopressin