Peptide LibraryResearch statistics
Corticorelin research: publications and trials
At a glance
Publications, all years
232
Since 1982
Publications in 2026 so far
0
Through November 1, 2026
Human clinical research
18.7%
43 of 230 classified
Registered clinical trials
14
ClinicalTrials.gov
Randomized controlled trials
3
Publications reporting an RCT in people
Systematic reviews and meta-analyses
0
Preclinical studies
78.7%
146 animal · 35 in vitro · 0 computational
Records that only mention it
66
Not counted above
Status in the library: FDA-approved. 2 publications are not yet classified by study type.
What to keep in mind
- More than 70% of the indexed publications are animal, cell or computational studies.
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Corticorelin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1982 | 0 | 6 | 0 | 0 | 6 |
| 1983 | 6 | 15 | 0 | 0 | 21 |
| 1984 | 9 | 15 | 1 | 0 | 25 |
| 1985 | 3 | 21 | 1 | 0 | 25 |
| 1986 | 3 | 14 | 1 | 0 | 18 |
| 1987 | 4 | 15 | 0 | 0 | 19 |
| 1988 | 1 | 11 | 0 | 1 | 13 |
| 1989 | 0 | 10 | 0 | 0 | 10 |
| 1990 | 1 | 7 | 0 | 0 | 8 |
| 1991 | 0 | 6 | 0 | 0 | 6 |
| 1992 | 1 | 5 | 0 | 0 | 6 |
| 1993 | 0 | 2 | 0 | 0 | 2 |
| 1994 | 1 | 2 | 0 | 1 | 4 |
| 1995 | 1 | 1 | 0 | 0 | 2 |
| 1996 | 0 | 9 | 0 | 0 | 9 |
| 1997 | 1 | 1 | 0 | 0 | 2 |
| 1998 | 0 | 6 | 0 | 0 | 6 |
| 1999 | 0 | 4 | 0 | 0 | 4 |
| 2000 | 0 | 6 | 0 | 0 | 6 |
| 2001 | 2 | 1 | 0 | 0 | 3 |
| 2002 | 1 | 2 | 0 | 0 | 3 |
| 2003 | 0 | 1 | 0 | 0 | 1 |
| 2004 | 0 | 6 | 1 | 0 | 7 |
| 2006 | 0 | 2 | 0 | 0 | 2 |
| 2007 | 0 | 3 | 0 | 0 | 3 |
| 2008 | 0 | 1 | 0 | 0 | 1 |
| 2009 | 0 | 1 | 1 | 0 | 2 |
| 2010 | 3 | 4 | 1 | 0 | 8 |
| 2011 | 1 | 1 | 0 | 0 | 2 |
| 2013 | 1 | 2 | 0 | 0 | 3 |
| 2014 | 1 | 0 | 0 | 0 | 1 |
| 2015 | 1 | 0 | 0 | 0 | 1 |
| 2016 | 2 | 0 | 0 | 0 | 2 |
| 2020 | 0 | 1 | 0 | 0 | 1 |
Study types
| Animal study | 146 |
|---|---|
| In vitro study | 35 |
| Other clinical trial | 32 |
| Observational human study | 6 |
| Review | 6 |
| Randomized controlled trial | 3 |
| Case report | 2 |
| Not yet classified | 2 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Neurological and mental health | 136 |
|---|---|
| Endocrinology | 124 |
| Musculoskeletal | 15 |
| Oncology | 14 |
| Cardiovascular | 13 |
| Gastrointestinal | 7 |
| Immune system | 7 |
| Obesity and weight management | 7 |
| Cognitive health | 6 |
| Metabolic health | 6 |
| Reproductive and sexual health | 5 |
| Longevity and aging | 2 |
Registered clinical trials
4 of 8 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 8 · Active, not recruiting: 2 · Terminated: 2 · Withdrawn: 2
Early phase 1: 2 · Phase not applicable: 3 · Phase 1: 3 · Phase 1 / Phase 2: 1 · Phase 2: 1 · Phase 3: 3 · Phase 4: 1
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Steroid-sparing effect of corticorelin acetate in peritumoral cerebral edema is associated with improvement in steroid-induced myopathy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · February 4, 2013 · Randomized controlled trial · cited 42 times · open access
PMID 23382470 · DOI 10.1200/jco.2012.43.9455 · Human clinical research
- Hypothalamus-pituitary-adrenal axis function in patients with rheumatoid arthritis treated with nighttime-release prednisone.
The Journal of rheumatology · August 3, 2010 · Randomized controlled trial · cited 93 times · open access
PMID 20682671 · DOI 10.3899/jrheum.100051 · Human clinical research
- A pharmacological tool to assess vasopressinergic co-activation of the hypothalamus-pituitary-adrenal axis more integrally in healthy volunteers.
Journal of psychopharmacology (Oxford, England) · February 10, 2010 · Randomized controlled trial · cited 3 times
PMID 20147570 · DOI 10.1177/0269881109358205 · Human clinical research
- Corticotropin-releasing hormone and dopamine release in healthy individuals.
Psychoneuroendocrinology · December 1, 2016 · Other clinical trial · cited 26 times
PMID 27951520 · DOI 10.1016/j.psyneuen.2016.11.034 · Human clinical research
- Neuroendocrine response to CRF stimulation in veterans with and without PTSD in consideration of war zone era.
Psychoneuroendocrinology · August 2, 2011 · Other clinical trial · cited 21 times
PMID 21813244 · DOI 10.1016/j.psyneuen.2011.07.004 · Human clinical research
- Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · September 24, 2002 · Other clinical trial · cited 44 times · open access
PMID 12629539 · DOI 10.1038/sj.npp.1300071 · Human clinical research
- Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse.
The American journal of psychiatry · April 1, 2001 · Other clinical trial · cited 745 times
PMID 11282691 · DOI 10.1176/appi.ajp.158.4.575 · Human clinical research
- [The necessity for perioperative cortisol substitution. Spontaneous and stimulated ACTH and cortisol secretion during unilateral adrenalectomy for renal cell carcinoma].
Der Anaesthesist · April 1, 1997 · Other clinical trial · cited 5 times
PMID 9229984 · DOI 10.1007/s001010050405 · Human clinical research
- Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment.
Archives of general psychiatry · March 1, 1995 · Other clinical trial · cited 210 times
PMID 7872849 · DOI 10.1001/archpsyc.1995.03950150045009 · Human clinical research
- Differing responses of cortisol to oCRF during endonasal and oral treatment with DDAVP.
European journal of clinical investigation · July 1, 1994 · Other clinical trial · cited 1 times
PMID 7957502 · DOI 10.1111/j.1365-2362.1994.tb02375.x · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.
Proceedings of the National Academy of Sciences of the United States of America · January 1, 1995 · In vitro study · cited 846 times · open access
PMID 7846062 · DOI 10.1073/pnas.92.3.836 · In vitro studies
- Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse.
The American journal of psychiatry · April 1, 2001 · Other clinical trial · cited 745 times
PMID 11282691 · DOI 10.1176/appi.ajp.158.4.575 · Human clinical research
- Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
The American journal of psychiatry · May 1, 1984 · Review · cited 481 times
PMID 6324597 · DOI 10.1176/ajp.141.5.619 · Reviews and meta-analyses
- Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study.
The Journal of neuroscience : the official journal of the Society for Neuroscience · December 1, 1985 · In vitro study · cited 478 times · open access
PMID 3001239 · DOI 10.1523/jneurosci.05-12-03189.1985 · In vitro studies
- Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat.
Science (New York, N.Y.) · May 1, 1984 · Animal study · cited 472 times
PMID 6326264 · DOI 10.1126/science.6326264 · Animal studies
Latest publications
- Identification of metabolites of peptide-derived drugs using an isotope-labeled reporter ion screening strategy.
Clinical chemistry and laboratory medicine · April 1, 2020 · In vitro study · cited 13 times
PMID 31860462 · DOI 10.1515/cclm-2019-1009 · In vitro studies
- Corticotropin-releasing hormone and dopamine release in healthy individuals.
Psychoneuroendocrinology · December 1, 2016 · Other clinical trial · cited 26 times
PMID 27951520 · DOI 10.1016/j.psyneuen.2016.11.034 · Human clinical research
- Bilateral inferior petrosal sinus sampling: experience in 327 patients.
Journal of neurointerventional surgery · February 15, 2016 · Observational human study · cited 52 times
PMID 26880723 · DOI 10.1136/neurintsurg-2015-012164 · Human clinical research
- Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review.
International journal of pediatric endocrinology · October 22, 2015 · Observational human study · cited 8 times · open access
PMID 26500680 · DOI 10.1186/s13633-015-0018-y · Human clinical research
- Paradoxical Results after Inadvertent Use of Cosyntropin [Adrenocorticotropin Hormone (1-24)] Rather than Acthrel (Ovine Corticotropin Releasing Hormone) during Inferior Petrosal Sinus Sampling.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · July 1, 2014 · Case report · cited 3 times · open access
PMID 24449668 · DOI 10.4158/ep13348.or · Human clinical research
- The role of PKC signaling in CRF-induced modulation of startle.
Psychopharmacology · May 31, 2013 · Animal study · cited 14 times · open access
PMID 23722830 · DOI 10.1007/s00213-013-3114-9 · Animal studies
- Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns.
Hormones and behavior · April 18, 2013 · Animal study · cited 19 times · open access
PMID 23603480 · DOI 10.1016/j.yhbeh.2013.04.001 · Animal studies
- Steroid-sparing effect of corticorelin acetate in peritumoral cerebral edema is associated with improvement in steroid-induced myopathy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · February 4, 2013 · Randomized controlled trial · cited 42 times · open access
PMID 23382470 · DOI 10.1200/jco.2012.43.9455 · Human clinical research
- Neuroendocrine response to CRF stimulation in veterans with and without PTSD in consideration of war zone era.
Psychoneuroendocrinology · August 2, 2011 · Other clinical trial · cited 21 times
PMID 21813244 · DOI 10.1016/j.psyneuen.2011.07.004 · Human clinical research
- Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research · March 8, 2011 · Animal study · cited 32 times · open access
PMID 21385926 · DOI 10.1158/1078-0432.ccr-10-3203 · Animal studies
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Acthrel; Corticobiss; Corticorelin; Corticorelina; Corticoreline; Ovine CRF; Xerecept
((TITLE_ABS:"Acthrel" OR CHEM:"Acthrel") OR (TITLE_ABS:"Corticobiss" OR CHEM:"Corticobiss") OR (TITLE_ABS:"Corticorelin" OR CHEM:"Corticorelin") OR (TITLE_ABS:"Corticorelina" OR CHEM:"Corticorelina") OR (TITLE_ABS:"Corticoreline" OR CHEM:"Corticoreline") OR (TITLE_ABS:"Ovine CRF" OR CHEM:"Ovine CRF") OR (TITLE_ABS:"Xerecept" OR CHEM:"Xerecept")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Corticorelin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/corticorelin