Peptide LibraryResearch statistics
Carbetocin research: publications and trials
At a glance
Publications, all years
388
Since 1979
Publications in 2026 so far
35
Through November 1, 2026
Human clinical research
44.2%
170 of 385 classified
Registered clinical trials
96
ClinicalTrials.gov
Randomized controlled trials
73
Publications reporting an RCT in people
Systematic reviews and meta-analyses
33
Preclinical studies
29.4%
82 animal · 19 in vitro · 12 computational
Records that only mention it
50
Not counted above
Status in the library: In clinical trials. 3 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Carbetocin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1979 | 0 | 1 | 0 | 0 | 1 |
| 1981 | 0 | 1 | 0 | 0 | 1 |
| 1982 | 0 | 1 | 0 | 0 | 1 |
| 1984 | 0 | 1 | 0 | 0 | 1 |
| 1987 | 0 | 1 | 0 | 0 | 1 |
| 1990 | 0 | 1 | 0 | 0 | 1 |
| 1991 | 0 | 3 | 0 | 0 | 3 |
| 1992 | 1 | 3 | 0 | 0 | 4 |
| 1993 | 1 | 0 | 0 | 0 | 1 |
| 1997 | 0 | 1 | 0 | 0 | 1 |
| 1998 | 2 | 1 | 0 | 0 | 3 |
| 1999 | 1 | 1 | 0 | 1 | 3 |
| 2000 | 0 | 2 | 0 | 0 | 2 |
| 2001 | 0 | 1 | 0 | 0 | 1 |
| 2004 | 1 | 0 | 1 | 0 | 2 |
| 2005 | 0 | 3 | 0 | 0 | 3 |
| 2006 | 1 | 1 | 0 | 0 | 2 |
| 2007 | 1 | 1 | 2 | 0 | 4 |
| 2008 | 0 | 2 | 1 | 1 | 4 |
| 2009 | 4 | 3 | 3 | 0 | 10 |
| 2010 | 2 | 4 | 1 | 2 | 9 |
| 2011 | 8 | 3 | 0 | 1 | 12 |
| 2012 | 5 | 2 | 2 | 0 | 9 |
| 2013 | 8 | 2 | 2 | 0 | 12 |
| 2014 | 2 | 4 | 0 | 1 | 7 |
| 2015 | 10 | 5 | 1 | 0 | 16 |
| 2016 | 10 | 5 | 2 | 0 | 17 |
| 2017 | 6 | 5 | 1 | 2 | 14 |
| 2018 | 11 | 6 | 5 | 5 | 27 |
| 2019 | 3 | 5 | 8 | 2 | 18 |
| 2020 | 4 | 5 | 3 | 2 | 14 |
| 2021 | 14 | 4 | 2 | 1 | 21 |
| 2022 | 6 | 8 | 7 | 5 | 26 |
| 2023 | 11 | 4 | 2 | 7 | 24 |
| 2024 | 15 | 6 | 5 | 4 | 30 |
| 2025 | 26 | 10 | 6 | 6 | 48 |
| 2026 (to date) | 17 | 7 | 6 | 5 | 35 |
Study types
| Animal study | 82 |
|---|---|
| Randomized controlled trial | 73 |
| Observational human study | 63 |
| Editorial, letter or other | 28 |
| Review | 27 |
| Other clinical trial | 25 |
| Meta-analysis | 23 |
| In vitro study | 19 |
| Computational study | 12 |
| Correction or retraction notice | 12 |
| Systematic review | 10 |
| Case report | 9 |
| Not yet classified | 3 |
| Guideline or consensus | 2 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Reproductive and sexual health | 283 |
|---|---|
| Cardiovascular | 42 |
| Neurological and mental health | 38 |
| Musculoskeletal | 21 |
| Cognitive health | 13 |
| Endocrinology | 12 |
| Obesity and weight management | 10 |
| Tissue repair | 5 |
| Antimicrobial and infectious disease | 4 |
| Metabolic health | 3 |
| Oncology | 3 |
| Immune system | 2 |
Registered clinical trials
33 of 62 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 62 · Unknown status: 21 · Recruiting: 8 · Not yet recruiting: 4 · Terminated: 1
Early phase 1: 3 · Phase not applicable: 44 · Phase 1: 2 · Phase 1 / Phase 2: 1 · Phase 2: 1 · Phase 2 / Phase 3: 1 · Phase 3: 11 · Phase 4: 33
The 50 most recently started of 96 trials.
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Carbetocin vs oxytocin for prevention of postpartum hemorrhage in women with obesity undergoing cesarean delivery: A systematic review and meta-analysis.
Journal of gynecology obstetrics and human reproduction · May 6, 2026 · Meta-analysis · cited 0 times
PMID 42102921 · DOI 10.1016/j.jogoh.2026.103208 · Reviews and meta-analyses
- Comparing oxytocin alternatives for postpartum hemorrhage prevention in vaginal and caesarean births: a systematic review and meta-analysis.
Archives of gynecology and obstetrics · April 28, 2026 · Meta-analysis · cited 0 times · open access
PMID 42050041 · DOI 10.1007/s00404-026-08368-5 · Reviews and meta-analyses
- Carbetocin in the Prevention of Postpartum Hemorrhage after Vaginal Birth: A Systematic Review and Meta-Analysis.
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · February 4, 2026 · Meta-analysis · cited 0 times · open access
PMID 42483292 · DOI 10.1097/fm9.0000000000000337 · Reviews and meta-analyses
- Carbetocin versus oxytocin in prevention of postpartum hemorrhage after cesarean delivery in high-risk women. A systematic review and meta-analysis.
Archives of gynecology and obstetrics · April 16, 2025 · Meta-analysis · cited 11 times · open access
PMID 40240535 · DOI 10.1007/s00404-025-08014-6 · Reviews and meta-analyses
- A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women.
The journal of obstetrics and gynaecology research · January 1, 2025 · Meta-analysis · cited 7 times · open access
PMID 39722234 · DOI 10.1111/jog.16194 · Reviews and meta-analyses
- Uterotonics for management of retained placenta.
The Cochrane database of systematic reviews · October 28, 2024 · Meta-analysis · cited 6 times · open access
PMID 39465684 · DOI 10.1002/14651858.cd016147 · Reviews and meta-analyses
- Effect of Carbetocin on Postpartum Hemorrhage after Vaginal Delivery: A Meta-Analysis.
Computational and mathematical methods in medicine · June 20, 2022 · Meta-analysis · cited 7 times · open access
PMID 35770122 · DOI 10.1155/2022/6420738 · Reviews and meta-analyses
- Efficacy of oxytocics on reducing intraoperative blood loss during abdominal myomectomy: A systematic review and meta-analysis of randomized placebo-controlled trials.
Journal of gynecology obstetrics and human reproduction · March 19, 2022 · Meta-analysis · cited 10 times
PMID 35314367 · DOI 10.1016/j.jogoh.2022.102358 · Reviews and meta-analyses
- Effectiveness and safety of carboxytocin versus oxytocin in preventing postpartum hemorrhage: A systematic review and meta-analysis.
The journal of obstetrics and gynaecology research · March 3, 2022 · Meta-analysis · cited 13 times
PMID 35243717 · DOI 10.1111/jog.15174 · Reviews and meta-analyses
- Side-effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta-analysis of randomized controlled trials.
Pharmacology research & perspectives · April 1, 2021 · Meta-analysis · cited 23 times · open access
PMID 33723868 · DOI 10.1002/prp2.745 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents.
Progress in brain research · January 1, 2008 · Review · cited 293 times
PMID 18655903 · DOI 10.1016/s0079-6123(08)00437-8 · Reviews and meta-analyses
- Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.
The Cochrane database of systematic reviews · April 25, 2018 · Systematic review · cited 236 times · open access
PMID 29693726 · DOI 10.1002/14651858.cd011689.pub2 · Reviews and meta-analyses
- Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.
The New England journal of medicine · June 27, 2018 · Randomized controlled trial · cited 210 times · open access
PMID 29949473 · DOI 10.1056/nejmoa1805489 · Human clinical research
- Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis.
Stem cells (Dayton, Ohio) · June 26, 2008 · Animal study · cited 204 times
PMID 18583541 · DOI 10.1634/stemcells.2008-0127 · Animal studies
- Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section.
American journal of obstetrics and gynecology · March 1, 1999 · Randomized controlled trial · cited 195 times
PMID 10076146 · DOI 10.1016/s0002-9378(99)70271-1 · Human clinical research
Latest publications
- Oxytocin versus Carbetocin: Preventing Postpartum Hemorrhage in Elective C-section.
Annals of African medicine · October 13, 2026 · Observational human study · cited 0 times
PMID 42860922 · DOI 10.4103/aam.aam_522_26 · Human clinical research
- Prophylactic Carbetocin Versus Oxytocin and Blood Loss After Vaginal Delivery: Agent Selection and Confounding by Indication in a Retrospective Cohort Study.
Medicina (Kaunas, Lithuania) · October 12, 2026 · Observational human study · cited 0 times · open access
PMID 42942498 · DOI 10.3390/medicina62101967 · Human clinical research
- Uncorking Quantitative and Qualitative Seminal Traits in French-Alpine Bucks via Carbetocin Stimulation to Enhance Goat Production in Semi-Arid Environments.
Animals : an open access journal from MDPI · October 8, 2026 · Animal study · cited 0 times · open access
PMID 42883126 · DOI 10.3390/ani16193157 · Animal studies
- The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled QT/QTc Study in Healthy Adults.
Clinical and translational science · October 1, 2026 · Randomized controlled trial · cited 0 times · open access
PMID 42802704 · DOI 10.1111/cts.70735 · Human clinical research
- Administering carbetocin before electroejaculation in bulls improves semen quality and increases the number of insemination doses.
Animal reproduction science · September 4, 2026 · Other clinical trial · cited 0 times
PMID 42705159 · DOI 10.1016/j.anireprosci.2026.108332 · Human clinical research
- Carbetocin versus oxytocin during elective cesarean delivery: A randomized double-blind trial.
Pakistan journal of medical sciences · September 1, 2026 · Randomized controlled trial · cited 0 times · open access
PMID 42819600 · DOI 10.12669/pjms.42.9.13879 · Human clinical research
- Untangling Mephedrone-Induced Social Reward in Rats-The Involvement of Oxytocin and Vasopressin V<sub>1A</sub> Receptors.
Genes, brain, and behavior · August 1, 2026 · Animal study · cited 0 times · open access
PMID 42429340 · DOI 10.1111/gbb.70057 · Animal studies
- Strategies for the Identification of Cyclic Peptide Drugs and Their Impurities.
Journal of the American Society for Mass Spectrometry · August 1, 2026 · In vitro study · cited 0 times
PMID 42463469 · DOI 10.1021/jasms.6c00023 · In vitro studies
- Replacing Routine Oxytocin Infusion With Single-Dose Carbetocin at Elective Caesarean Section: A Service Improvement Evaluation of Postpartum Haemorrhage Outcomes.
Cureus · August 1, 2026 · Observational human study · cited 0 times · open access
PMID 42677188 · DOI 10.7759/cureus.113782 · Human clinical research
- Carbetocin and peri-operative hemoglobin change at cesarean delivery in a setting of self-paid use: an 8-year retrospective cohort study.
BMC pregnancy and childbirth · July 27, 2026 · Observational human study · cited 0 times
PMID 42907989 · DOI 10.1186/s12884-026-09717-7 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Carbetocin; Carbetocina; Carbetocino; Carbetocinum; Depotocin; Duratocin; Lonactene; Pabal
((TITLE_ABS:"Carbetocin" OR CHEM:"Carbetocin") OR (TITLE_ABS:"Carbetocina" OR CHEM:"Carbetocina") OR (TITLE_ABS:"Carbetocino" OR CHEM:"Carbetocino") OR (TITLE_ABS:"Carbetocinum" OR CHEM:"Carbetocinum") OR (TITLE_ABS:"Depotocin" OR CHEM:"Depotocin") OR (TITLE_ABS:"Duratocin" OR CHEM:"Duratocin") OR (TITLE_ABS:"Lonactene" OR CHEM:"Lonactene") OR (TITLE_ABS:"Pabal" OR CHEM:"Pabal")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Carbetocin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/carbetocin