Peptide LibraryResearch statistics
BPC-157 research: publications and trials
At a glance
Publications, all years
228
Since 1992
Publications in 2026 so far
29
Through November 1, 2026
Human clinical research
1.8%
4 of 228 classified
Registered clinical trials
3
ClinicalTrials.gov
Randomized controlled trials
0
Publications reporting an RCT in people
Systematic reviews and meta-analyses
1
Preclinical studies
72.8%
156 animal · 10 in vitro · 0 computational
Records that only mention it
8
Not counted above
Status in the library: Research only. Groups: Tissue-repair peptides.
What to keep in mind
- Fewer than three randomized controlled trials are indexed.
- More than 70% of the indexed publications are animal, cell or computational studies.
Publications by year
BPC-157 publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1992 | 0 | 1 | 0 | 0 | 1 |
| 1993 | 0 | 1 | 1 | 0 | 2 |
| 1994 | 0 | 1 | 0 | 0 | 1 |
| 1995 | 0 | 1 | 0 | 0 | 1 |
| 1996 | 0 | 2 | 0 | 0 | 2 |
| 1997 | 0 | 10 | 0 | 0 | 10 |
| 1998 | 0 | 1 | 0 | 0 | 1 |
| 1999 | 0 | 8 | 1 | 0 | 9 |
| 2000 | 0 | 2 | 0 | 0 | 2 |
| 2001 | 0 | 9 | 0 | 0 | 9 |
| 2002 | 0 | 1 | 0 | 0 | 1 |
| 2003 | 0 | 3 | 0 | 0 | 3 |
| 2004 | 0 | 4 | 0 | 0 | 4 |
| 2005 | 0 | 4 | 0 | 0 | 4 |
| 2006 | 0 | 4 | 1 | 0 | 5 |
| 2007 | 0 | 3 | 0 | 0 | 3 |
| 2008 | 0 | 5 | 0 | 0 | 5 |
| 2009 | 0 | 8 | 0 | 0 | 8 |
| 2010 | 0 | 4 | 1 | 0 | 5 |
| 2011 | 0 | 4 | 1 | 0 | 5 |
| 2012 | 0 | 1 | 1 | 0 | 2 |
| 2013 | 0 | 3 | 1 | 0 | 4 |
| 2014 | 0 | 2 | 2 | 0 | 4 |
| 2015 | 0 | 6 | 0 | 0 | 6 |
| 2016 | 0 | 7 | 1 | 0 | 8 |
| 2017 | 0 | 8 | 1 | 0 | 9 |
| 2018 | 0 | 6 | 3 | 1 | 10 |
| 2019 | 0 | 4 | 1 | 0 | 5 |
| 2020 | 0 | 10 | 3 | 0 | 13 |
| 2021 | 1 | 14 | 2 | 0 | 17 |
| 2022 | 0 | 8 | 3 | 2 | 13 |
| 2023 | 0 | 6 | 2 | 1 | 9 |
| 2024 | 1 | 1 | 4 | 0 | 6 |
| 2025 | 1 | 2 | 6 | 3 | 12 |
| 2026 (to date) | 1 | 12 | 16 | 0 | 29 |
Study types
| Animal study | 156 |
|---|---|
| Review | 50 |
| In vitro study | 10 |
| Editorial, letter or other | 6 |
| Other clinical trial | 2 |
| Case report | 1 |
| Correction or retraction notice | 1 |
| Observational human study | 1 |
| Systematic review | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Gastrointestinal | 126 |
|---|---|
| Tissue repair | 93 |
| Cardiovascular | 65 |
| Neurological and mental health | 45 |
| Musculoskeletal | 32 |
| Immune system | 18 |
| Metabolic health | 15 |
| Dermatology | 8 |
| Endocrinology | 7 |
| Reproductive and sexual health | 7 |
| Antimicrobial and infectious disease | 5 |
| Cognitive health | 3 |
Registered clinical trials
A registration is not a result.
Not yet recruiting: 1 · Recruiting: 1 · Unknown status: 1
Phase 1: 2 · Phase 2: 1
| Trial | Status | Phase | Started | Results |
|---|---|---|---|---|
| Impact of BPC-157 on Recovery Following Rotator Cuff Repair SurgeryNCT07803250 · 30 enrolled | Not yet recruiting | Phase 1 | 2027-01 | — |
| BPC 157 for Acute Hamstring Muscle Strain RepairNCT07437547 · 120 enrolled | Recruiting | Phase 2 | 2026-02 | — |
| PCO-02 - Safety and Pharmacokinetics TrialNCT02637284 · 42 enrolled | Unknown status | Phase 1 | 2015-10 | — |
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety.
Acta orthopaedica Belgica · October 8, 2026 · Systematic review · cited 0 times · open access
PMID 42885452 · DOI 10.52628/92.3.15837 · Reviews and meta-analyses
- Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.
Alternative therapies in health and medicine · September 1, 2025 · Other clinical trial · cited 3 times
PMID 40131143 · Human clinical research
- Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.
Alternative therapies in health and medicine · October 1, 2024 · Other clinical trial · cited 5 times
PMID 39325560 · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure.
European journal of pharmacology · July 1, 1997 · Animal study · cited 138 times
PMID 9298922 · DOI 10.1016/s0014-2999(97)01033-9 · Animal studies
- BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.
The Journal of pharmacology and experimental therapeutics · January 1, 1995 · Animal study · cited 120 times
PMID 7815358 · DOI 10.1016/s0022-3565(25)24349-x · Animal studies
- Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression.
European journal of pharmacology · June 16, 2007 · Animal study · cited 111 times
PMID 17628536 · DOI 10.1016/j.ejphar.2007.05.072 · Animal studies
- The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.
Journal of applied physiology (Bethesda, Md. : 1985) · October 28, 2010 · In vitro study · cited 110 times
PMID 21030672 · DOI 10.1152/japplphysiol.00945.2010 · In vitro studies
- A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.
Journal of physiology, Paris · January 1, 1993 · Review · cited 100 times
PMID 8298609 · DOI 10.1016/0928-4257(93)90038-u · Reviews and meta-analyses
Latest publications
- Investigational Peptides in Orthopaedic Practice: Evidence, Safety, and Patient Counseling for BPC-157, Thymosin Beta-4, and TB-500.
The Journal of the American Academy of Orthopaedic Surgeons · October 27, 2026 · Review · cited 0 times
PMID 42937313 · DOI 10.5435/jaaos-d-26-00049 · Reviews and meta-analyses
- Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety.
Acta orthopaedica Belgica · October 8, 2026 · Systematic review · cited 0 times · open access
PMID 42885452 · DOI 10.52628/92.3.15837 · Reviews and meta-analyses
- Possibilities for Cytoprotective Liver Therapy, Stable Gastric Pentadecapeptide BPC 157, and Standard Agents-A Narrative Review.
Pharmaceuticals (Basel, Switzerland) · October 1, 2026 · Review · cited 0 times · open access
PMID 42943255 · DOI 10.3390/ph19101559 · Reviews and meta-analyses
- Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases.
Frontiers in oral health · September 30, 2026 · Case report · cited 0 times · open access
PMID 42876687 · DOI 10.3389/froh.2026.1907109 · Human clinical research
- BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence.
International journal of molecular sciences · September 19, 2026 · Review · cited 0 times · open access
PMID 42794771 · DOI 10.3390/ijms27188344 · Reviews and meta-analyses
- Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis.
Applied biochemistry and biotechnology · August 29, 2026 · Animal study · cited 0 times · open access
PMID 42667535 · DOI 10.1007/s12010-026-05885-6 · Animal studies
- Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.
Current pain and headache reports · August 24, 2026 · Review · cited 0 times
PMID 42635865 · DOI 10.1007/s11916-026-01542-z · Reviews and meta-analyses
- Peptide Supplements and Their Therapeutic Applications in Sports Medicine.
The American journal of sports medicine · August 11, 2026 · Review · cited 1 times · open access
PMID 42578445 · DOI 10.1177/03635465261464420 · Reviews and meta-analyses
- Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.
The Analyst · July 27, 2026 · In vitro study · cited 0 times
PMID 42328738 · DOI 10.1039/d6an00455e · In vitro studies
- Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.
Joint diseases and related surgery · July 23, 2026 · Animal study · cited 0 times · open access
PMID 42542926 · DOI 10.52312/jdrs.2026.2951 · Animal studies
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: BCP-157; Bepecin; Body Protection Compound 157; BPC-157; PL 14736
((TITLE_ABS:"BCP-157" OR CHEM:"BCP-157" OR TITLE_ABS:"BCP157" OR CHEM:"BCP157") OR (TITLE_ABS:"Bepecin" OR CHEM:"Bepecin") OR (TITLE_ABS:"Body Protection Compound 157" OR CHEM:"Body Protection Compound 157" OR TITLE_ABS:"Body Protection Compound157" OR CHEM:"Body Protection Compound157") OR (TITLE_ABS:"BPC-157" OR CHEM:"BPC-157" OR TITLE_ABS:"BPC157" OR CHEM:"BPC157") OR (TITLE_ABS:"PL 14736" OR CHEM:"PL 14736" OR TITLE_ABS:"PL14736" OR CHEM:"PL14736")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). BPC-157 research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/bpc-157