Peptide LibraryResearch statistics
Atosiban research: publications and trials
At a glance
Publications, all years
545
Since 1985
Publications in 2026 so far
17
Through November 1, 2026
Human clinical research
29.4%
158 of 538 classified
Registered clinical trials
22
ClinicalTrials.gov
Randomized controlled trials
56
Publications reporting an RCT in people
Systematic reviews and meta-analyses
29
Preclinical studies
51.3%
206 animal · 66 in vitro · 4 computational
Records that only mention it
106
Not counted above
Status in the library: In clinical trials. 7 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Atosiban publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1985 | 0 | 1 | 0 | 0 | 1 |
| 1986 | 2 | 1 | 0 | 0 | 3 |
| 1987 | 1 | 2 | 0 | 1 | 4 |
| 1988 | 0 | 1 | 0 | 1 | 2 |
| 1989 | 1 | 3 | 0 | 1 | 5 |
| 1991 | 0 | 1 | 0 | 0 | 1 |
| 1992 | 0 | 3 | 0 | 1 | 4 |
| 1993 | 2 | 1 | 0 | 0 | 3 |
| 1994 | 1 | 6 | 0 | 0 | 7 |
| 1995 | 3 | 6 | 2 | 1 | 12 |
| 1996 | 2 | 5 | 0 | 0 | 7 |
| 1997 | 0 | 4 | 0 | 0 | 4 |
| 1998 | 0 | 2 | 3 | 0 | 5 |
| 1999 | 0 | 8 | 0 | 1 | 9 |
| 2000 | 4 | 5 | 0 | 0 | 9 |
| 2001 | 4 | 8 | 4 | 0 | 16 |
| 2002 | 0 | 4 | 6 | 0 | 10 |
| 2003 | 4 | 9 | 4 | 1 | 18 |
| 2004 | 4 | 6 | 4 | 3 | 17 |
| 2005 | 3 | 16 | 3 | 3 | 25 |
| 2006 | 9 | 4 | 4 | 1 | 18 |
| 2007 | 7 | 8 | 2 | 2 | 19 |
| 2008 | 7 | 3 | 2 | 1 | 13 |
| 2009 | 9 | 7 | 4 | 2 | 22 |
| 2010 | 8 | 9 | 4 | 0 | 21 |
| 2011 | 5 | 7 | 1 | 2 | 15 |
| 2012 | 6 | 8 | 1 | 0 | 15 |
| 2013 | 6 | 8 | 3 | 0 | 17 |
| 2014 | 5 | 5 | 3 | 1 | 14 |
| 2015 | 0 | 7 | 0 | 0 | 7 |
| 2016 | 7 | 9 | 3 | 0 | 19 |
| 2017 | 4 | 13 | 3 | 1 | 21 |
| 2018 | 7 | 13 | 2 | 2 | 24 |
| 2019 | 6 | 10 | 3 | 3 | 22 |
| 2020 | 6 | 8 | 2 | 1 | 17 |
| 2021 | 5 | 11 | 2 | 1 | 19 |
| 2022 | 5 | 9 | 3 | 1 | 18 |
| 2023 | 7 | 9 | 2 | 1 | 19 |
| 2024 | 6 | 10 | 0 | 0 | 16 |
| 2025 | 8 | 15 | 2 | 5 | 30 |
| 2026 (to date) | 4 | 11 | 2 | 0 | 17 |
Study types
| Animal study | 206 |
|---|---|
| In vitro study | 66 |
| Randomized controlled trial | 56 |
| Observational human study | 47 |
| Review | 45 |
| Other clinical trial | 31 |
| Editorial, letter or other | 27 |
| Case report | 24 |
| Meta-analysis | 18 |
| Systematic review | 11 |
| Not yet classified | 7 |
| Computational study | 4 |
| Correction or retraction notice | 3 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Reproductive and sexual health | 332 |
|---|---|
| Neurological and mental health | 85 |
| Musculoskeletal | 62 |
| Cardiovascular | 55 |
| Endocrinology | 33 |
| Gastrointestinal | 30 |
| Cognitive health | 15 |
| Metabolic health | 14 |
| Immune system | 13 |
| Oncology | 11 |
| Antimicrobial and infectious disease | 7 |
| Tissue repair | 7 |
Registered clinical trials
5 of 12 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 12 · Unknown status: 5 · Recruiting: 3 · Terminated: 1 · Withdrawn: 1
Early phase 1: 2 · Phase not applicable: 6 · Phase 1: 2 · Phase 2: 4 · Phase 3: 4 · Phase 4: 4
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Atosiban versus nifedipine for the management of preterm labor: a systematic review and meta-analysis of randomized controlled trials.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · August 20, 2026 · Meta-analysis · cited 0 times
PMID 42923929 · DOI 10.61622/rbgo/2026rbgo55 · Reviews and meta-analyses
- An individual participant data network meta-analysis of the APOSTEL trials on the effect of tocolysis in threatened preterm birth between 30-33<sup>+6</sup> weeks of gestation in twin pregnancies.
European journal of obstetrics, gynecology, and reproductive biology · February 3, 2026 · Meta-analysis · cited 0 times · open access
PMID 41650841 · DOI 10.1016/j.ejogrb.2026.114989 · Reviews and meta-analyses
- Efficacy of atosiban for repeated embryo implantation failure: A systematic review and meta-analysis.
Frontiers in endocrinology · March 23, 2023 · Meta-analysis · cited 20 times · open access
PMID 37033236 · DOI 10.3389/fendo.2023.1161707 · Reviews and meta-analyses
- Tocolysis with nifedipine versus atosiban and perinatal outcome: an individual participant data meta-analysis.
BMC pregnancy and childbirth · July 15, 2022 · Meta-analysis · cited 15 times · open access
PMID 35840927 · DOI 10.1186/s12884-022-04854-1 · Reviews and meta-analyses
- Interventions to optimize embryo transfer in women undergoing assisted conception: a comprehensive systematic review and meta-analyses.
Human reproduction update · June 1, 2022 · Meta-analysis · cited 51 times · open access
PMID 35325124 · DOI 10.1093/humupd/dmac009 · Reviews and meta-analyses
- Is oxytocin receptor antagonist administration around embryo transfer associated with IVF treatment success? A systematic review and meta-analysis.
Reproductive biomedicine online · August 28, 2021 · Meta-analysis · cited 8 times
PMID 34686417 · DOI 10.1016/j.rbmo.2021.08.020 · Reviews and meta-analyses
- Usefulness of atosiban for tocolysis during external cephalic version: Systematic review and meta-analysis.
European journal of obstetrics, gynecology, and reproductive biology · December 31, 2020 · Meta-analysis · cited 17 times
PMID 33421816 · DOI 10.1016/j.ejogrb.2020.12.053 · Reviews and meta-analyses
- Atosiban improves the outcome of embryo transfer. A systematic review and meta-analysis of randomized and non-randomized trials.
JBRA assisted reproduction · October 6, 2020 · Meta-analysis · cited 18 times · open access
PMID 32401462 · DOI 10.5935/1518-0557.20200016 · Reviews and meta-analyses
- Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · March 13, 2019 · Meta-analysis · cited 31 times
PMID 30784056 · DOI 10.1002/ijgo.12793 · Reviews and meta-analyses
- Acute tocolysis for uterine tachysystole or suspected fetal distress.
The Cochrane database of systematic reviews · July 4, 2018 · Meta-analysis · cited 44 times · open access
PMID 29971813 · DOI 10.1002/14651858.cd009770.pub2 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.
Science (New York, N.Y.) · December 1, 2006 · Animal study · cited 485 times · open access
PMID 17170309 · DOI 10.1126/science.1133212 · Animal studies
- Tocolytic therapy for preterm delivery: systematic review and network meta-analysis.
BMJ (Clinical research ed.) · October 9, 2012 · Systematic review · cited 419 times · open access
PMID 23048010 · DOI 10.1136/bmj.e6226 · Reviews and meta-analyses
- An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue.
American journal of obstetrics and gynecology · May 1, 2000 · Randomized controlled trial · cited 321 times
PMID 10819855 · DOI 10.1067/mob.2000.95834 · Human clinical research
- Oxytocin receptor antagonists for inhibiting preterm labour.
The Cochrane database of systematic reviews · July 20, 2005 · Meta-analysis · cited 246 times · open access
PMID 16034931 · DOI 10.1002/14651858.cd004452.pub2 · Reviews and meta-analyses
- Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study.
American journal of obstetrics and gynecology · May 1, 2000 · Randomized controlled trial · cited 203 times
PMID 10819857 · DOI 10.1067/mob.2000.104950 · Human clinical research
Latest publications
- Characterization of cisternal, alveolar, and residual milk fractions in dromedary (Camelus dromedarius) and Bactrian camels (Camelus bactrianus).
Tropical animal health and production · October 10, 2026 · Animal study · cited 0 times
PMID 42859315 · DOI 10.1007/s11250-026-05386-y · Animal studies
- Pharmacological characterization of neuromodulatory systems involved in biased social interaction toward stressed conspecifics in male rats.
Social neuroscience · October 1, 2026 · Animal study · cited 0 times · open access
PMID 42820313 · DOI 10.1080/17470919.2026.2742155 · Animal studies
- Discovery of an antagonist nanobody targeting the oxytocin receptor with tocolytic effect in mice.
Nature communications · September 11, 2026 · Animal study · cited 0 times · open access
PMID 42864336 · DOI 10.1038/s41467-026-77680-0 · Animal studies
- Atosiban versus nifedipine for the management of preterm labor: a systematic review and meta-analysis of randomized controlled trials.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · August 20, 2026 · Meta-analysis · cited 0 times
PMID 42923929 · DOI 10.61622/rbgo/2026rbgo55 · Reviews and meta-analyses
- Role of the tail of the ventral tegmental area in the regulation of maternal behaviour: a pharmacological study in postpartum rats.
Neuropharmacology · August 16, 2026 · Animal study · cited 0 times · open access
PMID 42604662 · DOI 10.1016/j.neuropharm.2026.111147 · Animal studies
- Atosiban-Associated Non-cardiogenic Pulmonary Edema in a Dichorionic Diamniotic Twin Pregnancy: A Case Report.
Cureus · August 3, 2026 · Case report · cited 0 times · open access
PMID 42688486 · DOI 10.7759/cureus.113838 · Human clinical research
- Delicate Balance of Intra- and Inter-Molecular Entropic Effects in S-S Peptide Cyclization.
The journal of physical chemistry. A · August 1, 2026 · Computational study · cited 0 times
PMID 42593195 · DOI 10.1021/acs.jpca.6c02548 · Computational studies
- Strategies for the Identification of Cyclic Peptide Drugs and Their Impurities.
Journal of the American Society for Mass Spectrometry · August 1, 2026 · In vitro study · cited 0 times
PMID 42463469 · DOI 10.1021/jasms.6c00023 · In vitro studies
- Structural elucidation of succinimide-derived hydrolytic isomers of atosiban using a conventional CID-based Asp/IsoAsp discrimination strategy.
RSC advances · July 6, 2026 · In vitro study · cited 0 times · open access
PMID 42440966 · DOI 10.1039/d6ra03337g · In vitro studies
- Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.
Life (Basel, Switzerland) · June 19, 2026 · Animal study · cited 1 times · open access
PMID 42355554 · DOI 10.3390/life16061029 · Animal studies
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Antocile; Antocin; Atosiban; Atosibanum; ORF 22164; Tractocile
((TITLE_ABS:"Antocile" OR CHEM:"Antocile") OR (TITLE_ABS:"Antocin" OR CHEM:"Antocin") OR (TITLE_ABS:"Atosiban" OR CHEM:"Atosiban") OR (TITLE_ABS:"Atosibanum" OR CHEM:"Atosibanum") OR (TITLE_ABS:"ORF 22164" OR CHEM:"ORF 22164" OR TITLE_ABS:"ORF22164" OR CHEM:"ORF22164") OR (TITLE_ABS:"Tractocile" OR CHEM:"Tractocile")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Atosiban research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/atosiban