Peptide LibrarySecretin dosage in published studies and labels
These are the doses used for Secretin in FDA labelling and published clinical studies, reported as each source states them, one row per regimen. They describe what was studied or approved for a specific population. They are not a recommendation, and none of them is a dose for any individual.
Research and educational reference only. This is not medical advice, and no figure on this page is a dosing recommendation.
Last checked against primary sources:
Studied regimens and sources
Secretin has an FDA-approved human dosage only as a diagnostic agent. ChiRhoStim (human secretin) is a single intravenous injection over 1 minute: 0.2 mcg/kg to stimulate pancreatic secretions for pancreatic function testing or to find the ampulla during ERCP, and 0.4 mcg/kg to stimulate gastrin release when testing for gastrinoma.
| Human dosing established | Yes |
|---|---|
| Studied dose range | 0.2–0.4 mcg/kg once, intravenously, by test |
| Route | Intravenous |
| Frequency | Single injection per test |
| Duration studied | Single use |
| Evidence level | FDA Approved |
| Last reviewed | 2026-11-07 |
Research-reported dosing
Doses as studied, one row per regimen. Different trials used different regimens; they are listed separately rather than averaged.
| Study / context | Population | Dose | Route | Frequency | Duration | Outcome studied | Source |
|---|---|---|---|---|---|---|---|
| FDA label — ChiRhoStim, pancreatic function testingFDA-approved label · FDA prescribing information | Patients being tested for pancreatic exocrine dysfunction | 0.2 mcg/kg | Intravenous over 1 minute | Once, followed by timed duodenal fluid collection | Single dose | Stimulated pancreatic bicarbonate secretion for diagnosis | CHIRHOSTIM (human secretin) for injection — FDA prescribing information, DailyMed |
| FDA label — ChiRhoStim, gastrinoma testingFDA-approved label · FDA prescribing information | Patients being tested for gastrinoma, after a 12-hour fast | 0.4 mcg/kg | Intravenous over 1 minute | Once, with blood samples at 1, 2, 5, 10 and 30 minutes | Single dose | Stimulated gastrin release for diagnosis | CHIRHOSTIM (human secretin) for injection — FDA prescribing information, DailyMed |
| FDA label — ChiRhoStim, ERCPFDA-approved label · FDA prescribing information | Patients having ERCP when the ampulla of Vater or accessory papilla is hard to identify | 0.2 mcg/kg | Intravenous over 1 minute | Once | Single dose | Visible pancreatic fluid to identify the papillae | CHIRHOSTIM (human secretin) for injection — FDA prescribing information, DailyMed |
Where sources disagree
- Secretin's only approved uses are diagnostic tests given by clinicians. No label gives a repeated or treatment dose.
- ChiRhoStim is a synthetic human secretin powder reconstituted to 2 mcg/mL before injection. Porcine secretin products are not listed on DailyMed as of this review.