Kisspeptin-10
ExperimentalKisspeptin fragment / researchExperimental
Decapeptide KISS1 fragment that stimulates GnRH release. Used in reproductive-endocrine research. WADA lists kisspeptin and agonists as S2. Not FDA-approved.
For research use only.
Key Facts
- CAS
- 374675-21-5
- Molecular Weight (MW)
- 1302.5 g/mol
- Half-life
- ~4 minutes
- Unit
- mcg
- Administration Route
- Subcutaneous
- Frequency
- Every 48-72 hours
- Last updated
- 8/23/2026
- Targets
- KISS1R (GPR54)
Overview
Decapeptide KISS1 fragment that stimulates GnRH release. Used in reproductive-endocrine research. WADA lists kisspeptin and agonists as S2. Not FDA-approved.
Protocol
- Dosage Range
- 100-200 mcg per dose
- Frequency
- Every 48-72 hours
- Cycle
- 4-6 weeks on, 2-4 off
- Administration Route
- Subcutaneous
- Reconstitution Guide
- 3 mL BAC for 5 mg vial
Science
Mechanism of Action
Activates KISS1R (GPR54) on GnRH neurons, increasing LH/FSH. Short half-life requires frequent or infusion dosing in studies.
Targets
KISS1R (GPR54)
Studies
- Kisspeptin-10 stimulates gonadotropin release— Journal/year not available
Benefits
Reproductive-axis research
Potential Side Effects
- Flushing
- LH surge effects
References
- PMID 15919730External link · Year —
- WADA Prohibited List 2026External link · Year —