Humanin-G (HNG)
Humanin-G (HNG) is a potent humanin analog in the Mitochondrial Peptide class. Humanin is encoded within the mitochondrial 16S rRNA gene and acts both intracellularly, by interfering with Bax-mediated apoptosis, and extracellularly through a receptor complex involving CNTFR, WSX-1 and gp130.
For research use only.
Key Facts
- CAS
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- Molecular Weight (MW)
- —
- Half-life
- —
- FDA status
- Not Approved
- Administration Route
- subcutaneous
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Analog of the mitochondrial-derived peptide humanin carrying a serine-to-glycine substitution at position 14, reported in preclinical work to be substantially more potent than the parent peptide. Not FDA-approved; no human trials.
Peptide Library's Humanin-G (HNG) profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- —
- Frequency
- —
- Cycle
- —
- Administration Route
- subcutaneous
- Reconstitution Guide
- —
Science
Mechanism of Action
Humanin is encoded within the mitochondrial 16S rRNA gene and acts both intracellularly, by interfering with Bax-mediated apoptosis, and extracellularly through a receptor complex involving CNTFR, WSX-1 and gp130. The S14G substitution increases cytoprotective potency in cell and rodent models by orders of magnitude relative to wild-type humanin, which is why it is the form most often used in research.
Studies
- Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage
- Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells
- S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis
- Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
- Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats
Regulatory & research status
Humanin-G (HNG) is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Research status | Research-only compound; no approval pathway listed |
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
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Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Humanin-G (HNG): frequently asked questions
What is Humanin-G (HNG)?
Analog of the mitochondrial-derived peptide humanin carrying a serine-to-glycine substitution at position 14, reported in preclinical work to be substantially more potent than the parent peptide. Not FDA-approved; no human trials.
How does Humanin-G (HNG) work?
Humanin is encoded within the mitochondrial 16S rRNA gene and acts both intracellularly, by interfering with Bax-mediated apoptosis, and extracellularly through a receptor complex involving CNTFR, WSX-1 and gp130. The S14G substitution increases cytoprotective potency in cell and rodent models by orders of magnitude relative to wild-type humanin, which is why it is the form most often used in research.
Is Humanin-G (HNG) FDA approved?
No. Humanin-G (HNG) is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to Humanin-G (HNG)?
Compounds most often compared with Humanin-G (HNG) include MOTS-C, Humanin, SS-20 and Elamipretide (SS-31). They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage — Cell Death Dis, 2017External reference
- Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells — Am J Respir Cell Mol Biol, 2026External reference
- S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis — Eur J Pharmacol, 2026External reference
- Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats — Res Sq, 2026External reference
- Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats — Sci Rep, 2026External reference
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Humanin-G (HNG) profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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