LL-37

CosmeticHuman cathelicidin / researchExperimental

Human host-defense peptide (cathelicidin) with antimicrobial and immunomodulatory activity. Not FDA-approved as a drug; excess LL-37 is implicated in rosacea/psoriasis biology.

Calculate Dose

For research use only.

Key Facts

CAS: 154947-66-7
Molecular Weight (MW): 4493 Da
Half-life: ~1-2 hours
Unit: mcg
Administration Route: Subcutaneous
Frequency: Daily
Last updated: 8/23/2026
Targets: Microbial membranesInnate immune receptors

Overview

Human host-defense peptide (cathelicidin) with antimicrobial and immunomodulatory activity. Not FDA-approved as a drug; excess LL-37 is implicated in rosacea/psoriasis biology.

Protocol

Dosage Range: 100-500 mcg
Frequency: Daily
Cycle: 4-8 weeks on, 4-6 off
Administration Route: Subcutaneous
Reconstitution Guide: 3 mL BAC for 5 mg vial

Science

Mechanism of Action

Amphipathic helical peptide that disrupts microbial membranes and modulates TLR and vitamin-D–linked innate immunity. Overexpression can be proinflammatory in skin.