Vasoactive Intestinal Peptide (VIP)
Fat LossEndogenous neuropeptide / researchExperimental
28-aa neuropeptide vasodilator and VPAC agonist. Aviptadil (synthetic VIP) has been studied in pulmonary settings but VIP itself is not an FDA-approved general-use drug.
For research use only.
Key Facts
- CAS
- 37221-79-7
- Molecular Weight (MW)
- 3325.8 g/mol
- Half-life
- Not established (rapid enzymatic degradation; route dependent)
- Unit
- mg
- Administration Route
- Subcutaneous, Intramuscular, Intravenous, or Intranasal (investigational contexts)
- Frequency
- Not established
- Last updated
- 8/23/2026
- Targets
- VPAC1VPAC2
Overview
28-aa neuropeptide vasodilator and VPAC agonist. Aviptadil (synthetic VIP) has been studied in pulmonary settings but VIP itself is not an FDA-approved general-use drug.
Protocol
- Dosage Range
- Not established (research only)
- Frequency
- Not established
- Cycle
- Not established (research only; do not self-administer)
- Administration Route
- Subcutaneous, Intramuscular, Intravenous, or Intranasal (investigational contexts)
- Reconstitution Guide
- Reconstitute per lab SOP (commonly bacteriostatic water) and handle cold chain as required
Science
Mechanism of Action
Activates VPAC1/VPAC2 to raise cAMP, causing smooth-muscle relaxation, bronchodilation, and immunomodulation.
Targets
VPAC1VPAC2
Studies
- VIP physiology reviewโ Journal/year not available
Benefits
Pulmonary and neuro-endocrine research
Potential Side Effects
- Flushing
- Hypotension
- Diarrhea
References
- PMID 2980225External link ยท Year โ