Vasoactive Intestinal Peptide (VIP)

Fat LossEndogenous neuropeptide / researchExperimental

28-aa neuropeptide vasodilator and VPAC agonist. Aviptadil (synthetic VIP) has been studied in pulmonary settings but VIP itself is not an FDA-approved general-use drug.

Calculate Dose

For research use only.

Key Facts

CAS
37221-79-7
Molecular Weight (MW)
3325.8 g/mol
Half-life
Not established (rapid enzymatic degradation; route dependent)
Unit
mg
Administration Route
Subcutaneous, Intramuscular, Intravenous, or Intranasal (investigational contexts)
Frequency
Not established
Last updated
8/23/2026
Targets
VPAC1VPAC2

Overview

28-aa neuropeptide vasodilator and VPAC agonist. Aviptadil (synthetic VIP) has been studied in pulmonary settings but VIP itself is not an FDA-approved general-use drug.

Protocol

Dosage Range
Not established (research only)
Frequency
Not established
Cycle
Not established (research only; do not self-administer)
Administration Route
Subcutaneous, Intramuscular, Intravenous, or Intranasal (investigational contexts)
Reconstitution Guide
Reconstitute per lab SOP (commonly bacteriostatic water) and handle cold chain as required

Science

Mechanism of Action

Activates VPAC1/VPAC2 to raise cAMP, causing smooth-muscle relaxation, bronchodilation, and immunomodulation.

Targets

VPAC1VPAC2

Studies

Benefits

Pulmonary and neuro-endocrine research

Potential Side Effects

  • Flushing
  • Hypotension
  • Diarrhea

References

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