Glutathione

LongevityEndogenous tripeptide antioxidantExperimental

Endogenous antioxidant tripeptide sold as an oral supplement and used IV in clinics. Not FDA-approved as a standalone drug for systemic “detox” or skin-lightening claims.

Calculate Dose

For research use only.

Key Facts

CAS: 70-18-8
Molecular Weight (MW): 307.32 g/mol
Half-life: ~1.5 hours (IV); oral bioavailability limited
Unit: mg
Administration Route: Oral, Subcutaneous, Intramuscular, or IV
Frequency: 1-3x weekly (injectable) or daily (oral)
Last updated: 8/23/2026
Targets: Reactive oxygen speciesGlutathione peroxidase

Overview

Endogenous antioxidant tripeptide sold as an oral supplement and used IV in clinics. Not FDA-approved as a standalone drug for systemic “detox” or skin-lightening claims.

Protocol

Dosage Range: 250-2000 mg depending on route
Frequency: 1-3x weekly (injectable) or daily (oral)
Cycle: 4-12 weeks common; varies by research context
Administration Route: Oral, Subcutaneous, Intramuscular, or IV
Reconstitution Guide: Commonly reconstituted with bacteriostatic water for research use

May vary by vendor concentration and protocol.

Science

Mechanism of Action

Major intracellular thiol buffer; cofactor for glutathione peroxidases and GST enzymes. Oral bioavailability of reduced GSH is limited; IV use bypasses the gut.