Zinc Thymulin
Zinc Thymulin is a zinc-bound thymic nonapeptide. Thymulin is biologically inactive without a bound zinc ion, which fixes the peptide in its active conformation; the zinc-bound complex is therefore the physiologically relevant species. It has been studied for effects on T-cell differentiation and on inflammatory and nociceptive signalling.
For research use only.
Key Facts
- CAS
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- Molecular Weight (MW)
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- Half-life
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- FDA status
- Not Approved
- Administration Route
- topical, subcutaneous
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Zinc-complexed form of thymulin, the thymic nonapeptide that requires bound zinc for biological activity. Investigated for immune modulation and, topically, for hair growth. Not FDA-approved.
Peptide Library's Zinc Thymulin profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
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- Frequency
- —
- Cycle
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- Administration Route
- topical, subcutaneous
- Reconstitution Guide
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Science
Mechanism of Action
Thymulin is biologically inactive without a bound zinc ion, which fixes the peptide in its active conformation; the zinc-bound complex is therefore the physiologically relevant species. It has been studied for effects on T-cell differentiation and on inflammatory and nociceptive signalling. Topical interest in hair research stems from small studies of its effect on the hair follicle cycle, which remain preliminary.
Studies
- Different age-related effects of thymectomy in myasthenia gravis: role of thymoma, zinc, thymulin, IL-2 and IL-6
- Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2
- Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C
- Modulation of the neuroendocrine system and immune functions by zinc supplementation in children with Down's syndrome
- Immunodeficiency and cancer: prospects for correction
Regulatory & research status
Zinc Thymulin is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Research status | Research-only compound; no approval pathway listed |
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
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Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Cosmetic peptides in this library are formulated into topical products; follow the product label rather than the reconstitution guidance above.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Zinc Thymulin: frequently asked questions
What is Zinc Thymulin?
Zinc-complexed form of thymulin, the thymic nonapeptide that requires bound zinc for biological activity. Investigated for immune modulation and, topically, for hair growth. Not FDA-approved.
How does Zinc Thymulin work?
Thymulin is biologically inactive without a bound zinc ion, which fixes the peptide in its active conformation; the zinc-bound complex is therefore the physiologically relevant species. It has been studied for effects on T-cell differentiation and on inflammatory and nociceptive signalling.
Is Zinc Thymulin FDA approved?
No. Zinc Thymulin is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to Zinc Thymulin?
Compounds most often compared with Zinc Thymulin include Thymosin Alpha-1, Thymalin, Thymogen (Oglufanide) and Thymopentin. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Different age-related effects of thymectomy in myasthenia gravis: role of thymoma, zinc, thymulin, IL-2 and IL-6 — Mech Ageing Dev, 2000External reference
- Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2 — Int J Immunopharmacol, 1999External reference
- Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C — Proc Natl Acad Sci U S A, 1992External reference
- Modulation of the neuroendocrine system and immune functions by zinc supplementation in children with Down's syndrome — J Trace Elem Electrolytes Health Dis, 1993External reference
- Immunodeficiency and cancer: prospects for correction — Int Immunopharmacol, 2003External reference
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Zinc Thymulin profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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