why is there so little human data on most of these?

AskingForClarityAnalyst

Genuine question, not rhetorical. If some of these compounds have been around for decades, why has nobody run a proper trial?

7 replies5 upvotesBeginner Questions

7 replies

  • unconvinced_stillSenior Analyst

    Several reasons and they're not the same kind of reason. Money, phase 3 costs an enormous amount. Patentability, many of these are old or naturally derived. Regulatory pathway, you need a defined indication and "general wellbeing" isn't one. And some were tried and went nowhere. That's the one people forget.

    6 upvotes

    • AskingForClarityAnalyst

      The fourth one I hadn't considered.

      2 upvotes

  • unconvinced_stillSenior Analyst

    Several reasons and they're not the same kind of reason.

    Money — phase 3 costs an enormous amount. Patentability — many of these are old or naturally derived. Regulatory pathway — you need a defined indication. "General wellbeing" isn't a target. And some were tried and went nowhere. That's the one people forget.

    10 upvotes

    • AdminSenior Analyst

      if pharma companies are not going to end up making money from it they wont waste their time

      2 upvotes

  • same_tbhSenior Analyst

    the fourth one is brutal

    3 upvotes

  • PhaseTwoWatcherAnalyst

    Registries help a bit. You can sometimes see something registered and never reported.

    3 upvotes

  • quick_qSenior Analyst

    which ones were tried and went nowhere?

    2 upvotes

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